Simon Spurr

The biggest thing I'm seeing - and I have to be careful what I say here - is that people are tired of the old guard and the familiar brands. They're looking for more individuality and creativity, and that's coming out of this whole new wave of younger brands: Thom Browne, Michael Bastian, Robert Geller, myself.

The whole process of being one of the 10 finalists for the 'Vogue' Fashion Fund award has to be my biggest achievement to date. Meeting Anna Wintour, Diane von Furstenberg, etc., has been an amazing experience that even now gives me goose bumps when I think about it.

What do cells do when they see a broken piece of DNA? Cells don't like such breaks. They'll do pretty much anything they can to fix things up. If a chromosome is broken, the cells will repair the break using an intact chromosome.