Garry Shandling

My second or third year in the engineering department, I got very frustrated, and I sat down with myself and had a soul-searching conversation with myself and said, 'What I'd really like to do is see if I can write comedy.' ... I moved to L.A. stone cold. Didn't know anybody; didn't know how to go about it. Really started from scratch.

Here's the thing - I'm single, I haven't been married, I don't have kids yet. If I do have kids I would be interested to see them in my life, so here's a movie for kids and I'm in there and I'm supposed to be kind of funny for kids.

Software options proliferate extremely easily - too easily, in fact - because too many options create tools that can't ever be used intuitively. Intuitive actions confine the detail work to a dedicated part of the brain, leaving the rest of one's mind free to respond with attention and sensitivity to the changing texture of the moment.

Every time I see documentaries or infomercials about little kids with cancer, I just freak out. It affects me on the highest emotional level... Anytime I think about it, it makes me sadder than anything I can think of.

What do cells do when they see a broken piece of DNA? Cells don't like such breaks. They'll do pretty much anything they can to fix things up. If a chromosome is broken, the cells will repair the break using an intact chromosome.