Unfortunately it makes the unambiguous determination of triplets by these methods much more difficult than would be the case if there were only one triplet for each amino acid. Francis Crick acidaminocase Change image and share on social
It has yet to be shown by direct biochemical methods, as opposed to the indirect genetic evidence mentioned earlier, that the code is indeed a triplet code. Francis Crick biochemicalcodedirect Change image and share on social
The meaning of this observation is unclear, but it raises the unfortunate possibility of ambiguous triplets; that is, triplets which may code more than one amino acid. However one would certainly expect such triplets to be in a minority. Francis Crick acidambiguousamino share on social
Do codons overlap? In other words, as we read along the genetic message do we find a base which is a member of two or more codons? It now seems fairly certain that codons do not overlap. Francis Crick basecodonfairly Change image and share on social
Moreover the incorporation requires the same components needed for protein synthesis, and is inhibited by the same inhibitors. Thus the system is most unlikely to be a complete artefact and is very probably closely related to genuine protein synthesis. Francis Crick artefactcloselycomplete share on social
It now seems very likely that many of the 64 triplets, possibly most of them, may code one amino acid or another, and that in general several distinct triplets may code one amino acid. Francis Crick acidaminocode Change image and share on social
For simplicity one can think of the + class as having one extra base at some point or other in the genetic message and the - class as having one too few. Francis Crick baseclassextra Change image and share on social
A final proof of our ideas can only be obtained by detailed studies on the alterations produced in the amino acid sequence of a protein by mutations of the type discussed here. Francis Crick acidalterationamino Change image and share on social
It now seems certain that the amino acid sequence of any protein is determined by the sequence of bases in some region of a particular nucleic acid molecule. Francis Crick acidaminobasis Change image and share on social
