Cesar Milstein

Back in 1962, when I had by accident become the supervisor of Roberto Celis in Argentina, it occurred to me that antibody diversity might arise from the joining by disulphide bridges of a variety of small polypeptides in combinatorial patterns.

My interest in protein breakdown as a research problem began in l955 at about the time I joined the Biochemistry Department of Yale University. It was known that proteins break down intracellularly in the mature animal.