James Rothman

One of the major lessons in all of biochemistry, cell biology and molecular medicine is that when proteins operate at the sub cellular level, they behave in a certain way as if they're mechanical machinery.

I became aware of the very complex internal organization in a cell from the basic science classes, and it made me think about how all that could work. It seemed like a great mystery, especially how organelles in the cell can be arranged in three dimensions, and how thousands of proteins could find their way to the right location in the cells.

Sometimes the routes leading to feelings of anger are so convoluted and circuitous that it takes enormous skill to discern their original source, or fountainhead. But regardless of the reason for or the source of the anger or the relative ease or complexity in perceiving either the anger or its source - everybody, but everybody, gets angry.

What do cells do when they see a broken piece of DNA? Cells don't like such breaks. They'll do pretty much anything they can to fix things up. If a chromosome is broken, the cells will repair the break using an intact chromosome.