Francis Collins

The brain is the most complicated organ in the universe. We have learned a lot about other human organs. We know how the heart pumps and how the kidney does what it does. To a certain degree, we have read the letters of the human genome. But the brain has 100 billion neurons. Each one of those has about 10,000 connections.

If you are looking for a needle in a haystack, and somebody has already cataloged all the straw in the haystack, when you get to that needle you will recognize it's different than what was supposed to be there based on all that computerized haystack information that had been predetermined for you.

Genes are effectively one-dimensional. If you write down the sequence of A, C, G and T, that's kind of what you need to know about that gene. But proteins are three-dimensional. They have to be because we are three-dimensional, and we're made of those proteins. Otherwise we'd all sort of be linear, unimaginably weird creatures.

Like the 'little emperors' of one-child China, too many Boomers were taught early that the world was made (or saved) for their comfort and enjoyment. They behaved accordingly, with a self-indulgence that was wholly rational, given their situation.

You make your first album, you make some money, and you feel like you still have to show face, like 'I still go to the projects.' I'm like, why? Your job is to inspire people from your neighborhood to get out. You grew up there. What makes you think it's so cool?

What cracks me up is people who think I don't take baseball seriously. It's the most important thing in my life. They don't know how hard it is for me to get a bad game out of my mind. I still can't, but I'm getting better.