Daniel Nathans

Small science, which includes most research in the life sciences all over the world, is science directed usually by an individual senior scientist and a small team of junior associates, perhaps three, ten, fifteen, something in that order.

And I think that still is true of this business - which is basically research and development - that you probably spend more time in planning and training and designing for things to go wrong, and how you cope with them, than you do for things to go right.