Arthur Kornberg

I feel now, as we did then, that for an effective approach to the problem of nucleic acid biosynthesis, it was essential to understand the biosynthesis of the simple nucleotides and the coenzymes and to have these concepts and methodology well in hand.

By irreducibly complex I mean a single system composed of several well-matched, interacting parts that contribute to the basic function, wherein the removal of any one of the parts causes the system to effectively cease functioning.