Aaron Ciechanover

The development of methods to monitor protein dynamics in cells together with the discovery of specific and general lysosomal inhibitors have resulted in the identification of different classes of cellular proteins, long- and short-lived, and the findings of the differential effects of the inhibitors on these groups.

My interest in protein breakdown as a research problem began in l955 at about the time I joined the Biochemistry Department of Yale University. It was known that proteins break down intracellularly in the mature animal.

Our chemical and other manufacturing concerns are all too often ready to let the Germans have Latin American markets, provided the American companies can work out an arrangement which will enable them to charge high prices to the consumer inside the United States.