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By 1865, all Southern women - the happily and regrettably single, the perpetually engaged, the wives and widows - had tired of the war. The Confederacy was shrinking, and the morale of its remaining men shrinking with it.

By 1892, enlightenment had progressed to the point where the Salem trials were simply an embarrassing blot on the history of New England. They were a part of the past that was best forgotten: a reminder of how far the human race had come in two centuries.

By 1931, after a few years' experience of flying scheduled airlines, those planes were operating at roughly 600 times the safety of the space shuttle. I look at safety not in terms of fatalities per passenger-mile, but when you get in and close the door, what is the risk of dying on this flight?

By 1939, the Depression was back. Unemployment was huge. Roosevelt didn't have any quick fix. Remember, the New Deal, Works Progress Administration, and Civilian Conservation Corps - all that happened years before. Roosevelt was riding a storm.

By 1949, there was no more work for me out there, and I went to New York in 1950 and just did whatever I could. Mainly television. Some Broadway. A lot of dinner theater work, which is not a very satisfactory medium.

By 1951, television had already made such inroads on the income garnered by motion picture companies that the Golden Era which had prevailed until then was beginning to disintegrate. And by 1953, it had come to an end. Hollywood was a dismal, tragic place.

By 1954, as an assistant professor with a group of three graduate students, I was able to initiate more complex experimental projects, dealing with the structure, stereochemistry and synthesis of natural products. As a result of the success of this research, I was appointed in 1956, at age twenty-seven, as professor of chemistry.