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Stuxnet, a computer worm reportedly developed by the United States and Israel that destroyed Iranian nuclear centrifuges in attacks in 2009 and 2010, is often cited as the most dramatic use of a cyber weapon.

Stuxnet, Duqu and Flame are not normal, everyday malware, of course. All three of them were most likely developed by a Western intelligence agency as part of covert operations that weren't meant to be discovered. The fact that the malware evaded detection proves how well the attackers did their job.