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Science works because the phenomenon being described can be relied on to remain the same. Even in quantum physics, where phenomena are changed by observation, the way in which observation interferes is regular and falls within a limited range of possibilities. Human culture, however, has the nasty habit of never staying the same for very long.

Scientific corporations might well become almost independent states and be enabled to undertake their largest experiments without consulting the outside world - a world which would be less and less able to judge what the experiments were about.