The biggest development in reproductive biology is the birth-control pill. Nobody ever talks about it, but look at the consequences: demographics; aging populations; the sinking population of Europe, Japan; immigration. It's incredible.
‐‐ Gregory Stock
The biggest difference between British TV and American TV is money. But what money doesn't do on American TV, which I thought it would, is buy you time. You don't get more time. You get more toys.
‐‐ David Morrissey
The biggest difference between England and America is that England has history, while America has geography.
‐‐ Neil Gaiman
The biggest difference between Kennedy and Nixon, as far as the press is concerned, is simply this: Jack Kennedy really liked newspaper people and he really enjoyed sparring with journalists.
‐‐ Ben Bradlee
The biggest difference between L.A. and my hometown in Georgia is when Georgia goes to sleep, L.A. wakes up. So, like, in LaGrange, when people are going to sleep at 10, 11 to get up in the morning, we're just getting dressed to go out.
‐‐ Elijah Kelley
The biggest difference between me and other artists out there is that they'll put anything out to sell a record or sell a ticket.
‐‐ Corey Taylor
The biggest difference for me is momentum. On a smaller film you get to shoot sometimes four or five scenes a day and you've got to do the tight schedule. I think I really feel the luxuries of a big budget film.
‐‐ Joel Edgerton
The biggest difference in writing a sequel is that now there are expectations. But also - and this is the awesome part - now there are fans, too!
‐‐ Tim Federle
The biggest difference is in the leadership. It was better for us. We had more coaches and mentors to help us. A lot of the younger players today suffer from a lack of direction.
‐‐ Isaiah Thomas
The biggest difference with Twitter and writing long form is you're part of a virtual community where you know people, or think you know them, through their links.
‐‐ David Grann
The biggest direct influence on my career is Ben Edlund, who gave me my first real professional break and, through his friendship and example, turned me into a writer and a more critical thinker in general.
‐‐ Christopher McCulloch
The biggest disappointment has been seeing the number of people in this business with very shortsighted views.
‐‐ Greg Ginn
The biggest disease this day and age is that of people feeling unloved.
‐‐ Princess Diana
The biggest disease today is not leprosy or tuberculosis, but rather the feeling of being unwanted.
‐‐ Mother Teresa
The biggest downside of my current job is that I have to wear a suit to work. Wearing uncomfortable clothes on purpose is an example of what former Princeton hockey player and Nobel Prize winner Michael Spence taught economists to call 'signaling.'
‐‐ Ben Bernanke
The biggest edge I live on is directing. That's the most scary, dangerous thing you can do in your life.
‐‐ Tony Scott
The biggest effect celebrity had on me was that I stopped being open and receptive and started to walk around with my head down.
‐‐ David Schwimmer
The biggest emotion in creation is the bridge to optimism.
‐‐ Brian May
The biggest fatal flaw in most fictional portrayals of nanotech - what sends those books arcing across the room - is ignoring that the nanobots need energy to do... anything.
‐‐ Edward M. Lerner
The biggest fear I have is to die with regrets, and of course that will come true.
‐‐ Alexander Payne
The biggest financial pitfall in life is divorce. And the biggest reason for divorce is marriage.
‐‐ Gene Simmons
The biggest food-related risk in pregnancy is listeria. It's a dangerous bacteria, to which pregnant women are especially susceptible, that can lead to miscarriage or stillbirth.
‐‐ Emily Oster
The biggest fool in the world is he who merely does his work supremely well, without attending to appearance.
‐‐ Michael Korda
The biggest fragility in a project is often just the inability to be able to explain to people why you are doing it, and when you're going to do it, and what's going to happen.
‐‐ Sebastian Coe
The biggest game I ever played in was probably Don Larsen's perfect game.
‐‐ Mickey Mantle
The biggest gap there is in America is not economic; the gap is spiritual and cultural.
‐‐ Mike Huckabee
The biggest guru-mantra is: never share your secrets with anybody. It will destroy you.
‐‐ Chanakya
The biggest handicap in research is an ability to think outside the box. The handicap is being encumbered by all the conventional wisdom in a given field.
‐‐ Aubrey de Grey
The biggest hits - be they Coca-Cola or Doritos - owe their success to complex formulas that pique the taste buds enough to be alluring but don't have a distinct, overriding single flavor that tells the brain to stop eating.
‐‐ Michael Moss
The biggest honor of my career was when I won R&B Artist of the Year back in the 1970s. I look at that as a major honor.
‐‐ Daryl Hall
The biggest human temptation is to settle for too little.
‐‐ Thomas Merton
The biggest hurdle is figuring out who your friends are. Your real friends.
‐‐ Eleanor Mondale
The biggest hurdle is rejection. Any business you start, be ready for it. The difference between successful people and unsuccessful people is the successful people do all the things the unsuccessful people don't want to do. When 10 doors are slammed in your face, go to door number 11 enthusiastically, with a smile on your face.
‐‐ John Paul DeJoria
The biggest hurdle to writing Fargo Rock City was that I couldn't afford a home computer - I had to get a new job so I could buy a computer. It could all change though. In five years, I could be back at some daily newspaper, which wouldn't be so bad.
‐‐ Chuck Klosterman
The biggest impact I can have for what I want to do, the results I want to have with what God's given me, is to help as many people as possible get to heaven.
‐‐ Thomas Monaghan
The biggest impact my father had on my life was teaching the importance of literacy.
‐‐ Thomas Steinbeck
The biggest impediment to growth is in our minds and not in the world outside, and only constant in the world is change.
‐‐ N. R. Narayana Murthy
The biggest influence? I've had several at different times - but the biggest for me was Bob Dylan, who was a guy that came along when I was twelve or thirteen and just changed all the rules about what it meant to write songs.
‐‐ Jackson Browne
The biggest influence on my books was the fact that I had worked in a newspaper for so long. In a daily paper, you learn to write very quickly; there is no time to sit and brood about what you are going to say.
‐‐ Maeve Binchy
The biggest ingredient in a best friend is someone whose actions you respect and who you can truly be yourself around.
‐‐ Renee Olstead
The biggest insecurity I had was my singing. Even though I had sold 70 million records, there was this feeling like, I'm not good at this.
‐‐ Jennifer Lopez
The biggest inspiration for everything I do is, of course, my wife, playwright Ruth McKee.
‐‐ Brian K. Vaughan
The biggest insult is that I've been called an exaggerator... I tell the truth as I know it. I don't glamorize the nightmare and horror that I witness; I just digest it and spew it back, with venom.
‐‐ Lydia Lunch
The biggest invention of modern time is the book. The book is a digital medium; book text is written in a different form and replicable. What it really does is it allows us to replicate cultural information, scientific technology, and information out of the human brain.
‐‐ Sebastian Thrun
The biggest issue about the height factor is the bias that the NFL has about it.
‐‐ Doug Flutie
The biggest issue by far is that carbohydrates are absolutely at the cornerstone of all of our major degenerative conditions.
‐‐ David Perlmutter
The biggest job we have is to teach a newly hired employee how to fail intelligently. We have to train him to experiment over and over and to keep on trying and failing until he learns what will work.
‐‐ Charles Kettering
The biggest kick I get is to communicate with those who are exiled from the game - in hospitals, homes, prisons - those who have seldom seen a game, who can't travel to a game, those who are blind.
‐‐ Jack Buck
The biggest klutz would be myself, so if I could offer help to myself I would. I'm the most off my game most often.
‐‐ Bridgit Mendler